Table 4. Association of the SNPs with CCT, VCDR, IOP, AL in controls and POAG (HTG/NTG/combined).
SNP | Minor allele | Control (n = 371) | NTG (n = 31) | HTG (n = 66) | Combined (n = 97) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
β | SE | P * | β | SE | P * | β | SE | P * | β | SE | P * | ||
CCT | N = 369 | N = 27 | N = 63 | N = 87 | |||||||||
rs1900004 | T | 0.34∞ | 0.46∞ | 0.31¶ | 0.29£ | ||||||||
rs3858145 | G | 0.16¶ | 0.48£ | 0.21£ | 0.32∞ | ||||||||
rs10483727 | C | 0.21∞ | 0.59£ | 0.08£ | 0.15¶ | ||||||||
rs1063192 | C | 0.17∞ | 0.11£ | 0.08∞ | 0.27∞ | ||||||||
rs9607469 | A | 0.4£ | 0.79¶ | 0.53£ | 0.27£ | ||||||||
rs1192415 | G | 0.11 ∞ | 0.65£ | 0.38∞ | 0.14∞ | ||||||||
VCDR | N = 363 | N = 21 | N = 45 | N = 66 | |||||||||
rs1900004 | T | −0.028 | 0.012 | 0.013¶ | .39∞ | 0.41¶ | 0.48¶ | ||||||
rs3858145 | G | 0.18∞ | .42£ | 0.39£ | 0.43¶ | ||||||||
rs10483727 | C | 0.27£ | −0.102 | 0.04 | 0.017∞ | 0.3∞ | −0.062 | 0.025 | 0.014∞ | ||||
rs1063192 | C | 0.19¶ | 0.13£ | 0.18£ | 0.52£ | ||||||||
rs9607469 | A | 0.27£ | 0.4£ | −0.141 | 0.06 | 0.022∞ | 0.07∞ | ||||||
rs1192415 | G | 0.12∞ | 0.16¶ | 0.52£ | 0.34¶ | ||||||||
IOP | N = 369 | N = 27 | N = 54 | N = 81 | |||||||||
rs1900004 | T | 0.2£ | 0.23¶ | −0.042 | 0.02 | 0.042¶ | 0.29£ | ||||||
rs3858145 | G | 0.62∞ | 0.21¶ | 0.2£ | 0.27∞ | ||||||||
rs10483727 | C | 0.11£ | 0.23∞ | 0.07∞ | 0.75∞ | ||||||||
rs1063192 | C | 0.14£ | 0.72£ | 0.59∞ | 0.36£ | ||||||||
rs9607469 | A | 0.69£ | 0.57£ | 0.21£ | 0.68∞ | ||||||||
rs1192415 | G | 0.21¶ | 0.15∞ | 0.51£ | 0.59£ | ||||||||
AL | N = 74 | N = 39 | |||||||||||
rs1900004 | T | 0.49∞ | - | - | 0.11∞ | ||||||||
rs3858145 | G | 0.29£ | - | - | 0.45£ | ||||||||
rs10483727 | C | 0.26∞ | - | - | 0.21∞ | ||||||||
rs1063192 | C | −0.388 | 0.15 | 0.012¶ | - | - | 0.17£ | ||||||
rs9607469 | A | 0.22£ | - | - | 0.46∞ | ||||||||
rs1192415 | G | 0.62£ | - | - | 0. 07£ |
β = standard regression coefficient
SE = standard error
£- dominant model
∞- recessive model
¶-additive model
*Obtained from linear regression
Bonferroni adjusted significant level< = 0.008 (0.05/6)