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. Author manuscript; available in PMC: 2016 Jan 6.
Published in final edited form as: Cell Metab. 2014 Dec 24;21(1):21–31. doi: 10.1016/j.cmet.2014.11.019

Figure 1. Hypothalamic neuronal cilia regulate energy metabolism.

Figure 1

Neuronal cilia emanating from POMC-expressing neurons regulate obesity phenotypes in the ciliopathies. Under normal conditions, neuronal cilia and the BBSome complex may serve to modulate signaling from the leptin receptor and/or other receptor complexes. Upon perturbation of the cilium, mistrafficking of receptor complexes leads to the inactivation of STAT3 and to dysfunctional cellular signaling.