Table 2.
Hazard ratios of RA by quartiles of aMED Score*
| aMed Score
|
|||||
|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | p for trend | |
| All RA | |||||
| NHS | |||||
| Cases/ Person-years | 164/510,785 | 139/508,567 | 173/531,429 | 155/524,681 | |
| Age adjusted | 1.00 | 0.85(0.68,1.07) | 1.01(0.81,1.25) | 0.89(0.71,1.11) | 0.56 |
| Multivariable adjusted | 1.00 | 0.87(0.69,1.09) | 1.04(0.83,1.30) | 0.94(0.73,1.20) | 0.91 |
| NHS II | |||||
| Cases/ Person-years | 75/315,806 | 72/460,984 | 54/300,158 | 81/358,641 | |
| Age adjusted | 1.00 | 0.65(0.47,0.91) | 0.71(0.50,1.00) | 0.88(0.64,1.21) | 0.58 |
| Multivariable adjusted | 1.00 | 0.71(0.51,0.98) | 0.80(0.55,1.16) | 1.09(0.75,1.57) | 0.60 |
| NHS and NHS II pooled | |||||
| Age adjusted | 1.00 | 0.78(0.65, 0.94) | 0.91(0.76, 1.10) | 0.89(0.74, 1.06) | 0.43 |
| Multivariable adjusted | 1.00 | 0.81(0.67, 0.98) | 0.97(0.80, 1.18) | 0.98(0.80, 1.20) | 0.85 |
|
| |||||
| Seropositive RA | |||||
| NHS | |||||
| Cases/ Person-years | 103/481,583 | 90/479,660 | 98/497,621 | 100/429,830 | |
| Age adjusted | 1.00 | 0.89(0.67,1.19) | 0.92(0.70,1.22) | 0.94(0.71,1.24) | 0.74 |
| Multivariable adjusted | 1.00 | 0.93(0.70,1.24) | 0.98(0.73,1.31) | 1.03(0.76,1.40) | 0.79 |
| NHS II | |||||
| Cases/ Person-years | 50/310,102 | 48/452,201 | 30/295,056 | 58/352,392 | |
| Age adjusted | 1.00 | 0.66(0.44,0.98) | 0.58(0.37,0.92) | 0.96(0.66,1.41) | 0.75 |
| Multivariable adjusted | 1.00 | 0.73(0.48,1.09) | 0.70(0.43,1.12) | 1.26(0.81,1.98) | 0.43 |
| NHS and NHS II pooled | |||||
| Age adjusted | 1.00 | 0.81(0.64, 1.02) | 0.81(0.64, 1.03) | 0.95(0.76, 1.19) | 0.65 |
| Multivariable adjusted | 1.00 | 0.85(0.68, 1.08) | 0.89(0.69, 1.14) | 1.10(0.85, 1.42) | 0.51 |
|
| |||||
| Seronegative RA | |||||
| NHS | |||||
| Cases/ Person-years | 61/509,353 | 49/507,020 | 75/529,827 | 55/522,969 | |
| Age adjusted | 1.00 | 0.79(0.54,1.15) | 1.15(0.82,1.62) | 0.82(0.56,1.18) | 0.64 |
| Multivariable adjusted | 1.00 | 0.78(0.53,1.15) | 1.14(0.79,1.63) | 0.80(0.53,1.20) | 0.61 |
| NHS II | |||||
| Cases /Person-years | 25/315,231 | 24/460,221 | 24/299,590 | 23/357,938 | |
| Age adjusted | 1.00 | 0.64(0.36,1.12) | 0.95(0.54,1.67) | 0.73(0.41,1.29) | 0.60 |
| Multivariable adjusted | 1.00 | 0.66(0.37,1.18) | 0.99(0.54,1.80) | 0.81(0.43,1.55) | 0.87 |
| NHS and NHS II pooled | |||||
| Age adjusted | 1.00 | 0.74(0.54, 1.01) | 1.09(0.82, 1.47) | 0.79(0.58, 1.08) | 0.50 |
| Multivariable adjusted | 1.00 | 0.74(0.54, 1.02) | 1.10(0.80, 1.49) | 0.80(0.57, 1.13) | 0.60 |
aMed = Alternate Mediterranean Diet Score; NHS = Nurses’ Health Study; NHS II =Nurses’ Health Study II; RA= rheumatoid arthritis.
Adjusted for age, census tract median family income (quartiles), cigarette smoking status (never, past, current 1–14 cigarettes/day, current ≥15 cigarettes/day), age at menarche (<12, 12, >12 years), parity and breast feeding (nulliparous, parous/no breastfeeding, parous/1–12 months breastfeeding, parous/>12 months breastfeeding), hormone use (pre-menopausal, post-menopausal with never use, current use and past use), physical activity (0–3, 3–9, 9–18, 18–27, ≥27 METs /week), body mass index (<20, 20–22.9, 23–24.9, 25–29.9, ≥30kg/m2), multi-vitamin use, diabetes history, sugar-sweetened soda (<1 month, 1–4/month, 2–6/week, >1/day), coffee consumption (<1/day, 1–2/day, 3–4/day, >=4/day) and total energy (Kcal, quintiles).