Table VI.
Particle Size Distribution (d 0.1, d 0.5 and d 0.9) of Ibuprofen Powder Blends (1–5) and Granules (I1-I11) Measured by Laser Diffraction at 0.1 and 0 Bar, Respectively
| Ibuprofen | HPMC | Rol (MPa) | d0.1(μm) | d0.5(μm) | d0.9(μm) | |
|---|---|---|---|---|---|---|
| Blend 1 | small | small | na | 24 | 99 | 774 |
| I1 | 3 | 20 | 137 | 805 | ||
| I3 | 8 | 19 | 119 | 643 | ||
| Blend 2 | small | large | na | 32 | 146 | 730 |
| I2 | 3 | 22 | 207 | 937 | ||
| I4 | 8 | 29 | 318 | 1089 | ||
| Blend 3 | large | small | na | 27 | 121 | 422 |
| I5 | 3 | 21 | 151 | 849 | ||
| I7 | 8 | 24 | 212 | 915 | ||
| Blend 4 | large | large | na | 44 | 183 | 645 |
| I6 | 3 | 25 | 226 | 1067 | ||
| I8 | 8 | 24 | 196 | 817 | ||
| Blend 5 | CP | CP | na | 31 | 140 | 920 |
| I9 | 5.5 | 22 | 185 | 817 | ||
| I10 | 5.5 | 20 | 129 | 860 | ||
| I11 | 5.5 | 22 | 174 | 917 |
na not applicable, CP centre point