Table IV.

Pharmacokinetic Parameters After Administration of AC Plain Tablet, AC Proniosome Powder, and AC Proniosome-Loaded Tablet

Formulation	C max (ng/ml)	T max (h)	K ele (h)	t 1/2 ele (h)	AUC0–24 (ng/ml/h)	AUC0–∞ (ng/ml/h)	Cl (ml/h)	Relative bioavailability (%)
AC plain tablet
IND	2827 ± 510	4	0.104 ± 0.019	6.75 ± 1.24	20,643 ± 1856	26,730 ± 2174	0.033 ± 0.005	−
AC	596 ± 98	2	0.066 ± 0.005	10.21 ± 0.63	7919 ± 2079	11,517 ± 2718	0.053 ± 0.011	−
AC proniosome powder
IND	3427 ± 524	8	0.081 ± 0.019	8.87 ± 2.24	37,512 ± 5623	48,292 ± 4040	0.013 ± 0.005	180.06
AC	1102 ± 146	4	0.077 ± 0.018	9.37 ± 2.33	14,278 ± 1150	17,314 ± 1940	0.033 ± 0.005	150.33
AC proniosome-loaded tablet
IND	2534 ± 473	12	0.037 ± 0.003	18.61 ± 1.38	39,533 ± 4071	69,273 ± 1193	0.013 ± 0.005	259.15
AC	1261 ± 151	6	0.041 ± 0.006	17.55 ± 2.42	17,996 ± 777	32,248 ± 3465	0.016 ± 0.005	280.00

AC acemetacin, IND indomethacin