Table 3.

Hazard Ratios for Primary and Secondary Outcomes Across Diet Drink Consumption Strata

Models	Outcomes
	Cardiovascular events	Cardiac death	Overall death
	HR (95 % CI)	HR (95 % CI)	HR (95 % CI)
Model I*	N: 59,614	N: 59,447	N: 59,447
0–3/month	1.0	1.0	1.0
1–4/week	0.9 (0.9–1.02)	0.8 (0.7–0.99)	0.9 (0.8–0.9)
5–7/week	1.0 (0.9–1.1)	0.8 (0.6–0.99)	0.8 (0.8–0.9)
≥ 2/day	1.2 (1.04–1.3)	0.9 (0.7–1.2)	1.0 (0.9–1.1)
Model II†	N: 55,073	N: 55,073	N: 55,073
0–3/month	1.0	1.0	1.0
1–4/week	1.0 (0.96–1.1)	1.0 (0.8–1.2)	1.0 (0.9–1.1)
5–7/week	1.1 (1.0–1.3)	1.1 (0.9–1.4)	1.1 (1.0–1.2)
≥ 2/day	1.6 (1.4–1.9)	1.8 (1.3–2.4)	1.5 (1.3–1.7)
Model III‡	N: 53,037	N: 53,037	N: 53,037
0–3/month	1.0	1.0	1.0
1–4/week	1.0 (0.9–1.1)	0.9 (0.8–1.1)	1.0 (0.9–1.1)
5–7/week	1.0 (0.9–1.1)	1.0 (0.8–1.3)	1.1 (1.0–1.2)
≥ 2/day	1.3 (1.2–1.5)	1.4 (1.04–1.9)	1.4 (1.2–1.6)
Model IV§	N: 33,619∥	N: 33,619∥	N: 33,619∥
0–3/month	1.0	1.0	1.0
1–4/week	1.0 (0.9–1.1)	0.9 (0.7–1.2)	1.0 (0.9–1.1)
5–7/week	1.1 (0.9–1.2)	0.9 (0.7–1.3)	1.1 (0.9–1.2)
≥ 2/day	1.3 (1.1–1.5)	1.5 (1.03–2.3)	1.3 (1.04–1.5)

HR hazard ratios, CI confidence intervals

*Model I was unadjusted

^†Model II was adjusted for age, race, education and income

^‡Model III was adjusted for the variables in Model II plus smoking status, BMI, and a history of diabetes, hypertension and hyperlipidemia

^§Model IV was adjusted for the variables in Model III plus alcohol intake, log calibrated energy intake, physical activity, sugar-sweetened beverage intake, salt intake, and hormone therapy. Adjusted cardiac event models were stratified on hypertension, and high cholesterol and adjusted mortality models were stratified on hypertension and the history of diabetes because these variables did not meet the proportional hazards assumption

^∥The majority of loss of patients in model 4 was secondary to missing data for salt intake and calibrated energy