. 2014 Dec 2;11(1):85–95. doi: 10.1007/s13181-014-0448-6

Table 2.

Comparison of dabigatran with ideal characteristics for hemodialysis [1, 2, 28–32]

	Ideal characteristics	Dabigatran	Dialyzability?
Molecular weight (daltons)	<500	471.5	Yes
Protein binding	<80 %	35 %	Yes
Volume of distribution (V _d)	<1.0 L/kg	0.7–1.0 L/kg^a	Questionable^b
Water solubility	Yes	Slightly soluble^c	Questionable
Net increase in plasma clearance by hemodialysis	≥30 %	62–67 %	Yes

^aBased on a 70-kg patient and V _d reported in product labeling of 50–70 L

^bApparent volume of distribution during the terminal phase has been reported as 2.4–26.6 L/kg (based on a 70-kg patient) depending on the population studied [32]

^cThe water solubility for dabigatran etexilate (prodrug) is 1.8 mg/mL. There is no value reported in the literature for dabigatran (active moiety)