Table 2. Association of haplotype-tagging SNPs of SERPING1 with neovascular AMD and PCV.
| Allelic Distribution (%) | Allelic Association (P value) Odds Ratio (95% Confidence Intervals) | Genotype Distribution (%) | Genotypic Association (P value) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP ID | AMD | PCV | Control | AMD-Control | PCV-Control | PCV-AMD | AMD (n = 200) | PCV (n = 233) | Control (n = 275) | AMD-Control | PCV-Control | ||
| rs1005510 | G | 80 (20.10) | 99 (21.43) | 123 (22.36) | 0.40 | 0.72 | 0.63 | GG | 10 (5.03) | 11 (4.76) | 15 (5.45) | 0.67a | 0.94a |
| A | 318 (79.90) | 363 (78.57) | 427 (77.64) | 0.87 (0.64–1.2) | 0.95 (0.70–1.28) | 1.08 (0.78–1.51) | AG | 60 (30.15) | 77 (33.33) | 93 (33.82) | 0.39b | 0.85b | |
| AA | 129 (64.82) | 143 (61.91) | 167 (60.73) | 1.00c | 0.84c | ||||||||
| rs11603020 | C | 38 (9.55) | 45 (9.74) | 57 (10.36) | 0.68 | 0.74 | 0.92 | CC | 1 (0.50) | 1 (0.43) | 2 (0.73) | 0.92a | 0.96a |
| T | 360 (90.45) | 417 (90.26) | 493 (89.64) | 0.91 (0.59–1.41) | 0.93 (0.62–1.41) | 1.02 (0.65–1.61) | CT | 36 (18.09) | 43 (18.62) | 53 (19.27) | 0.73b | 0.82b | |
| TT | 162 (81.41) | 187 (80.95) | 220 (80.00) | 1.00c | 1.00c | ||||||||
agenotypic association;
bassociation in the dominant model;
cassociation in the recessive model;
AMD: age related macular degeneration; PCV: polypoidal choroidal vasculopathy; SNP: single nucleotide polymorphism.