Table 2.
Results of meta-analysis testing in the CD247 gene with SLE
| Asian | European | African | Hispanic / Amerindian | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP ID | SNP reference | Position (Mb) | Gene region | Allelesa | P-value | OR[95% CI] | Allelesa | P-value | OR[95% CI] | Allelesa | P-value | OR[95% CI] | Allelesa | P-value | OR[95% CI] | Pmeta |
| 5 | rs1052230 | 165666706 | 3′ UTR | C/G | 0.2575 | 1.08[0.94-1.24] | C/G | 0.9290 | 1.00[0.90-1.10] | C/G | 0.4898 | 1.05[0.92-1.20] | C/G | 0.8993 | 1.01[0.83-1.23] | 0.4442 |
| 9 | rs1723023 | 165671757 | Intron 4 | A/G | 0.2060 | 0.89[0.74-1.07] | A/G | 0.5936 | 0.98[0.92-1.05] | A/G | 0.0924 | 0.86[0.73-1.03] | A/G | 0.7990 | 0.98[0.85-1.13] | 0.0771 |
| 11 | rs1404567 | 165675499 | Intron 2 | G/A | 0.6690 | 0.97[0.86-1.10] | G/A | 0.2269 | 0.94[0.85-1.04] | G/A | 0.1472 | 1.14[0.95-1.37] | G/A | 0.8441 | 0.98[0.80-1.20] | 0.7039 |
| 12 | rs1554669 | 165682416 | Intron 1 | G/A | 0.4660 | 1.06[0.91-1.24] | G/A | 0.1464 | 0.90[0.79-1.04] | G/A | 0.1958 | 1.08[0.96-1.21] | G/A | 0.9670 | 1.00[0.82-1.21] | 0.9154 |
| 14 | rs7523907 | 165693872 | Intron 1 | G/A | 3.00E-02 | 0.80[0.66-0.98] | G/A | 2.85E-02 | 0.93[0.86-0.99] | G/A | 0.8992 | 1.01[0.91-1.11] | G/A | 0.6858 | 0.97[0.85-1.11] | 1.40E-02 |
| 15 | rs1723015 | 165699519 | Intron 1 | A/G | 0.1485 | 1.09[0.97-1.21] | G/A | 1.83E-02 | 0.92[0.86-0.99] | G/A | 0.9620 | 1.00[0.91-1.10] | G/A | 0.6715 | 1.03[0.91-1.17] | 3.97E-02 |
| 17 | rs2995091 | 165700902 | Intron 1 | G/A | 1.50E-02 | 0.78[0.64-0.95] | G/A | 0.1160 | 0.95[0.88-1.01] | G/A | 0.4225 | 0.93[0.79-1.10] | G/A | 0.9499 | 1.00[0.86-1.15] | 1.42E-02 |
| 19 | rs12036775 | 165703672 | Intron 1 | A/G | 0.4529 | 0.95[0.84-1.08] | A/G | 0.0931 | 1.06[0.99-1.14] | A/G | 0.1951 | 1.07[0.97-1.19] | A/G | 0.3792 | 1.06[0.93-1.20] | 0.0707 |
| 20 | rs7523351 | 165703888 | Intron 1 | G/C | 0.1479 | 1.10[0.97-1.25] | G/C | 0.6238 | 1.03[0.92-1.15] | G/C | 0.2454 | 0.93[0.83-1.05] | G/C | 0.1771 | 0.87[0.70-1.07] | 0.8799 |
| 21 | rs2949659 | 165706163 | Intron 1 | G/A | 0.6102 | 1.03[0.92-1.16] | G/A | 0.9564 | 1.00[0.88-1.13] | G/A | 0.6354 | 1.03[0.92-1.16] | G/A | 0.5844 | 0.95[0.81-1.13] | 0.8530 |
| 24 | rs1214611 | 165715729 | Intron 1 | A/G | 7.81E-03 | 1.17[1.04-1.30] | A/G | 0.6487 | 0.98[0.92-1.05] | G/A | 2.95E-02 | 1.11[1.01-1.23] | A/G | 0.2017 | 0.92[0.81-1.05] | 0.4358 |
| 26 | rs12737372 | 165717740 | Intron 1 | A/G | 1.96E-02 | 0.88[0.78-0.98] | A/G | 0.3261 | 0.96[0.89-1.04] | A/G | 0.4384 | 1.08[0.90-1.29] | A/G | 0.6820 | 1.03[0.89-1.20] | 0.2823 |
| 27 | rs12141731 | 165718065 | Intron 1 | A/G | 1.25E-02 | 0.87[0.78-0.97] | A/G | 0.2225 | 0.96[0.89-1.03] | A/G | 0.2380 | 1.10[0.94-1.29] | A/G | 0.6833 | 1.03[0.90-1.18] | 0.2664 |
| 30 | rs12144621 | 165720283 | Intron 1 | G/C | 3.91E-03 | 1.18[1.05-1.32] | C/G | 0.6756 | 1.02[0.94-1.10] | C/G | 0.2346 | 1.08[0.95-1.23] | C/G | 0.7843 | 1.02[0.88-1.18] | 0.8532 |
| 31 | rs858554 | 165721539 | Intron 1 | A/G | 4.99E-04 | 1.32[1.13-1.55] | A/G | 0.2795 | 1.04[0.97-1.11] | A/G | 0.6303 | 1.03[0.93-1.13] | G/A | 0.2774 | 0.93[0.82-1.06] | 5.80E-03 |
| 35 | rs858545 | 165728016 | Intron 1 | A/C | 1.41E-02 | 1.17[1.03-1.32] | A/C | 4.51E-02 | 1.07[1.00-1.15] | C/A | 5.92E-03 | 1.15[1.04-1.27] | A/C | 0.3180 | 1.07[0.94-1.22] | 0.1583 |
| 36 | rs704848* | 165728498 | Intron 1 | G/C | 1.36E-02 | 1.16[1.03-1.31] | C/G | 1.12E-02 | 0.92[0.85-0.98] | C/G | 0.5043 | 1.04[0.93-1.16] | C/G | 3.39E-02 | 0.87[0.76-0.99] | 1.40E-03 |
| 38 | rs10918706 | 165732746 | Intron 1 | A/G | 0.3030 | 1.06[0.95-1.20] | A/G | 0.2756 | 0.96[0.89-1.03] | A/G | 0.6949 | 1.03[0.89-1.20] | A/G | 0.8676 | 1.01[0.86-1.20] | 0.9309 |
| 39 | rs858543 | 165733923 | Intron 1 | G/A | 0.0797 | 1.10[0.99-1.23] | A/G | 0.6240 | 1.02[0.94-1.10] | A/G | 0.5157 | 1.04[0.93-1.16] | A/G | 0.0677 | 1.15[0.99-1.32] | 0.5225 |
Abbreviations: Mb, Megabases; Pmeta, meta-analysis P-values; Pmetacorr, Bonferroni corrected meta-analysis P-values; OR, odds ratio; 95% CI, 95% confidence interval.
a
minor/major allele.
*
rs704848 marker is still significant after Bonferroni correction for multiple testing (Pmeta=2.66×10−2).
The meta-analysis P-values are under the additive model and adjusted for the first three principal components and gender. Only SNPs with association results in the four study populations were tested. Significant P-values (<0.05) are highlighted in bold.