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. Author manuscript; available in PMC: 2015 Oct 24.
Published in final edited form as: Circ Res. 2014 Sep 16;115(10):845–856. doi: 10.1161/CIRCRESAHA.115.304356

Figure 7. Doxorubicin treatment leads to loss of myofibrils in vivo.

Figure 7

Doxorubicin was injected into the pericardial cavity at 4.5 dpf and the larvae raised for another 24 hours. Subsequent confocal imaging revealed a significant effect on overall myofibril structure and density. While vehicle-injected control larvae showed no detectable alterations (A, A′), injection of 1 pL (4 mmol/L) doxorubicin entirely ablated fine myofibrils in compact wall cardiomyocytes and caused myofibrillar disarray in the thick myofibrils in trabecular cardiomyocytes (B, B′). A′ and B′ are also available as 3-D reconstructions (Online Movies Va and Vb respectively).