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. 2015 Apr;22(4):225–231. doi: 10.1101/lm.036699.114

Figure 2.

Figure 2.

Systemic administration of 10 mg/kg RGFP963 enhances consolidation of cued fear extinction. (A) Fear conditioning and extinction paradigm. No significant differences in freezing behavior between groups prior to drug administration were observed during grouping or extinction training (n = 12/group). Twenty-four and 48 h later, subjects were tested for retention of extinction training with 15 CS trials. Extinction retention was defined as average freezing to the first 5 CS trials of the 15 CS test. (B) Repeated-measures ANOVA revealed a significant main effect of drug on freezing across extinction retention days 1 and 2 (P < 0.05). A post hoc least significant difference (LSD) test revealed significant differences between 10 mg/kg RGFP963 versus vehicle and 10 mg/kg RGFP963 versus 10 mg/kg RGFP966 (P < 0.05). (C) No significant differences in within-session extinction were detected between groups on extinction training, extinction retention 1, or extinction retention 2 test days.