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. 2015 Apr;22(4):203–214. doi: 10.1101/lm.037713.114

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© 2015 Stiver et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Muscarinic cholinergic receptor blockade with scopolamine prevents novelty-induced destabilization of strongly encoded object memories. (A) Object recognition performance by rats in Experiment 2a (n = 10). Coadministration of scopolamine (Sc) before memory reactivation blocked the MK-801-induced memory reconsolidation impairment observed when strongly encoded object memories (from three sampling sessions) were reactivated in the presence of a salient novel contextual cue (“insert”). Separate one-sample t-tests versus chance (0) indicated that rats in all drug conditions except for Saline/MK-801 showed significant novel object preference in the choice phase. (B) Experiment 2b (n = 10), in which the reactivation phase was conducted without the novel cue, confirmed that the MK-801-induced deficit was reliant on the presence of salient novelty in the reactivation phase. Rats in all conditions discriminated significantly above chance according to one-sample t-tests. Data are presented as average discrimination ratio ± SEM. (*) P < 0.05; (**) P < 0.01.