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. 2015 Apr;22(4):197–202. doi: 10.1101/lm.036590.114

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© 2015 Vecsey et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first 12 months after the full-issue publication date (see http://learnmem.cshlp.org/site/misc/terms.xhtml). After 12 months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 2. — Sleep deprivation after training in aged mice impairs memory at 1 d, but not 30 d, after training. Training, SD, and testing procedures for aged (22- to 23-mo old) C57BL/6 NIA mice were the same as shown in Figure 1A. (A) In aged mice, SD significantly reduced freezing in the trained context during the 1-d test, but had no significant effect on freezing during the Remote test. (B) SD did not have a significant effect on freezing in the altered context, which lessened over time in both the FC Alone and FCSD groups, similar to what was observed in young mice. (C) SD impaired the specificity of memory for the trained context during the Recent memory test, but had no effect during the Remote test. Aged FCSD mice showed a significant improvement in the specificity of memory over time, whereas aged FC Alone mice did not. Data are graphed as the mean ± SEM. (#) A significant overall effect of testing time, (+) a significant overall effect of SD, and (*) a significant post hoc comparison following a significant interaction between SD and testing time (P ≤ 0.05 was considered significant). Number of animals: FC Alone Recent = 20, FCSD Recent = 19, FC Alone Remote = 23, FCSD Remote = 24.