Table IV In vitro antiprotozoan, cytotoxic and antiproliferative activities of extracts from endophytic fungi of Caesalpinia echinata Lam. (Fabaceae).
| Fungal isolate(WC) | Tumour cell lineages(%) | PBMC(%) | Protozoan(%) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| UACC-62 | TK-10 | MCF-7 | Mortality | Proliferation decreased | LA | TC | |||
| Aspergillus sp.(25) | - | 103 ± 9 | - | - | - | - | - | ||
| Epicoccum sorghi (45) | 75 ± 7 | 47 ± 10 | 67 ± 9 | - | - | - | - | ||
| E. sorghi (46) | - | 97 ± 5 | 60 ± 17 | - | 15 ± 7 | - | - | ||
| Fusarium sp. (9) | - | 98 ± 5 | 88 ± 4 | - | 15 ± 8 | 45 ± 0 | 92 ± 4 | ||
| Fusarium sp.(58) | - | - | 48 ± 10 | 49 ± 26 | - | 45± 4 | - | ||
| Nectria pseudotrichia (2) | - | 54 ± 14 | 68 ± 4 | NT | NT | - | - | ||
| N. pseudotrichia (6) | - | 95 ± 7 | 93 ± 0 | NT | NT | - | - | ||
| N. pseudotrichia (33) | 102 ± 7 | 96 ± 15 | 60 ± 11 | - | 37 ± 15 | 77 ± 3 | - | ||
| Talaromyces sp. (24) | - | 95 ± 9 | 60 ± 7 | - | 20 ± 13 | - | - | ||
| Xylaria arbuscula (1) | - | 60 ± 1 | 57 ± 9 | - | - | - | - | ||
| Xylaria sp. (11) | - | 113 ± 3 | 47 ± 8 | NT | NT | 51 ± 1 | - | ||
| Xylaria berteri (41) | - | 43± 6 | - | - | 20 ± 15 | - | - | ||
| Xylaria sp.(55) | - | 92 ± 4 | 58 ± 0 | - | - | - | - | ||
| Xylaria sp.(84) | - | 51±9 | 48 ± 8 | NT | NT | - | - | ||
| Controls | |||||||||
| AMB | NT | NT | NT | NT | NT | 82 ± 3 | NT | ||
| BNZ | NT | NT | NT | NT | NT | NT | 86 ± 8 | ||
| ETO | 176 ± 9 | 185 ± 9 | 100 ± 5 | 33 ± 14 | NT | NT | NT | ||
| DEX | NT | NT | NT | 18 ± 13 | - | NT | NT | ||
| ALL | NT | NT | NT | - | 21 ± 14 | NT | NT | ||
all extracts were tested at 20 µg/mL. Results were expressed in terms of percentage of the inhibition. ALL: allopurinol tested at 20 µg/mL; AMB: amphotericin B tested at 0.02 µg/mL; BNZ: benznidazole tested at 1.0 µg/mL = 3.8 µM; DEX: dexamethasone tested at 20 µg/mL; ETO: etoposide tested at 1.6 µg/mL in tumour cell lineages and at 20 µg/mL in human peripheral blood mononuclear cell (PBMC); LA: amastigotes forms of Leishmania (Leishmania) amazonensis; MCF-7: human breast cancer; NT: not tested; TC: amastigote and trypomastigote forms of Trypanosoma cruzi; TK-10: human renal cancer; UACC-62: human melanoma cancer; WC: working code; -: inactive;