Table 1.
Low dose | High dose | |
---|---|---|
Sporozoites (liver-stage parasites) | Mosquito bite or 100 sporozoites iv: no pre-erythrocytic immunity (Figure 3A/B) | 10,000 sporozoites iv: pre-erythrocytic immunity (Figure 3B) |
Blood-stage parasites | Blood-stage infection curtailed by chloroquine: partial blood-stage immunity (Figure 4) | Fulminant, self-cured blood-stage infection: blood-stage immunity (Spence et al., 2013); pre-erythrocytic immunity (Figure 6) |