Table 2.
Differences between non-users, low dose users, intermediate dose users and high dose users on RT as analyzed in 2823 NESDA participants
| No BZD | Low dose ≤0,5 DDD | Intermediate dose >0.5–1 DDD | High dose >1 DDD | ||
|---|---|---|---|---|---|
| n = 2404 | n = 288 | n = 74 | n = 57 | ||
| Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | Mean (95% CI) | P | |
| Unadjusted | 0.95 (0.94, 0.96) | 1.03 (1.00, 1.06) | 1.11 (1.04, 1.18) | 1.19 (1.11, 1.29) | <0.001 |
| Adjusted | 0.96 (0.95, 0.97) | 0.97 (0.95, 0.99) | 0.99 (0.95, 1.05) | 1.03 (0.97, 1.10) | 0.01 |
1 DDD was defined as 10 mg diazepam equivalents day−1. The adjusted analysis was adjusted for sociodemographic characteristics (gender, age, education level), health indicators (alcohol intake and presence of a somatic disease), severity of psychopathology (BAI and IDS-mc), daily dose of used antidepressants, duration of BZD use and number of mistakes made in the IAT. P was obtained by ancova (analysis for linear trend). Significance was inferred at P < 0.05. BZD, benzodiazepines; CI, confidence interval; DDD, defined daily dose; RT, reaction time.