Table 3.
Summary of identified pathogens, MICs and time above MICs
| Identified bacteria | Number of patients | MIC (μg ml−1)* | f t>MIC%† | ||
|---|---|---|---|---|---|
| S. pneumonia | 11 | 0.06 | 0.06–2.00 | 98.1 | (6.46) |
| H. influenza | 8 | 0.50 | 0.12–4.00 | 84.7 | (23.4) |
| M. catarrhalis | 8 | 0.12 | 0.06–0.12 | 100 | (0.00) |
| E. coli | 1 | 4.00 | NA | 94.0 | (NA) |
| K. oxytoca | 1 | 16.00 | NA | 44.7 | (NA) |
| S. aureus | 1 | 0.12 | NA | 100 | (NA) |
| K. pneumonia | 1 | 4.00 | NA | 100 | (NA) |
| E. aerogenes | 1 | 4.00 | NA | 78.5 | (NA) |
NA = not applicable. *Median (range) as ampicillin concentration. †Mean (SD) fraction of time above MIC for treatment period as unbound plasma ampicillin concentration assuming the free fraction was 0.72.