Table 2.

Estimation of constants (parameters) for Verhulst and Monod models

Parameter	D1		D2			D3			D4
	B	FB	B	BFB	CFB	B	BFB	CFB	B	CFB
KV-PB	16.53	16.89	14.846	15.538	15.703	NM	NM	NM	15.567	16.769
rV-PB	0.0165	0.0142	0.0183	0.0185	0.016	NM	NM	NM	0.015	0.011
KV-SB	NM	NM	14.956	16.20	16.250	NM	NM	NM	16.113	17.007
rV-SB	NM	NM	0.0186	0.0154	0.014	NM	NM	NM	0.0130	0.010
KV-MAb	6.29	6.80	NM	NM	NM	NM	NM	NM	NM	NM
rV-MAb	0.0365	0.0313	NM	NM	NM	NM	NM	NM	NM	NM
KG	NM	NM	3.70E−05	3.70E−05	3.70E−05	1.046	1.046	1.046	1.00E−07	1.00E−07
KGt	NM	NM	3.40E−09	3.40E−09	3.40E−09	0.159	0.159	0.159	0.07	0.07
KL	NM	NM	21.49	21.49	21.49	38.43	38.43	38.43	118	118.0
KA	NM	NM	5.14E+2	5.14E+2	5.14E+2	1.27E+3	1.27E+3	1.27E+3	15.7	15.7

Verhulst parameter values for cell line CHOK1 SV (MAb) (D1), CHO 320 (IFN-γ) (D2), CHO IFN-γ (D4): K_V-PB, r_V-PB, K_V-SB, r_V-SB, K_V-MAb and r_V-MAb; Monod parameter values for the cell lines CHO 320 (IFN-γ) (D2), CHO 320 (IFN-γ) (D3) and CHO IFN-γ (D4)

NM not measured