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Inhibitory activity of girolline on flagellin stimulated THP1 derived macrophages and fresh human PBMCs. Girolline pre-treatment decreased IL-8 secretion (a) and NF-κB activity (b) after flagellin stimulation. The same inhibitory activity was observed with PBMCs, where both IL-8 (c) and IL-6 (d) levels were significantly reduced after girolline pre-treatment. Flg: flagellin.
