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The inhibitory activity of girolline on TLR signaling. Dose-dependent inhibition profiles were examined following stimulation of a variety of TLRs, as well as IL-1R and TNFR, using HEK-TLR2 (a), HEK-TLR3 (b) HEK-TLR4 (c) and HEK-TLR7 (d) reporter cells. A simplified TLR signaling pathway was illustrated in (e).
