TABLE 1.
Histological and immunohistochemical differential diagnoses of mammary and extramammary Paget's disease
| METHODS | Primary extramammary | Secondary extramammary | Bowen's disease melanoma | Superficial spreading |
|---|---|---|---|---|
| Paget's disease | Paget's disease | |||
| PAS diastase resistant | + | + | - | - |
| Mayer's mucicarmine | + | + | - | - |
| Alcian Blue | + | + | - | - |
| Colloidal iron | + | + | - | - |
| Fontana Masson | - | - | - | + |
| Pancytokeratin (AE1AE3) | + | + | + | - |
| CK7 | + | + | + or - | - |
| EMA | + | + | ||
| CEA | + | + | - | - |
| GCDFP-15 | + | - | - | - |
| Melan-A | - | - | - | + |
| P63 | - | - | + | |
| S100 protein | - | - | - | + |
| HMB45 | - | - | - | + |