Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Mar 24;6:85. doi: 10.3389/fphys.2015.00085

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Brandauer, Andersen, Kellezi, Risis, Frøsig, Vienberg and Treebak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Increases in quadriceps SIRT3 protein levels after repeated AICAR treatment are abolished in AMPK α2 KD mouse skeletal muscle. Levels of (A) SIRT3 protein, (B) SIRT3 mRNA, (C) MnSOD protein, (D) MnSOD mRNA, (E) SIRT1 protein, and (F) Catalase protein were determined in quadriceps muscle from WT and AMPK α2 KD male mice (n = 7–8) treated with daily subcutaneous injections of AICAR (500 mg/kg body weight) or saline for 4 weeks. Values are mean ± SEM. Interaction effects (treatment × genotype) were present in (A) (p < 0.05) and (C) (p < 0.01). ^* indicates vs. saline within genotype (p < 0.05), ^** indicates vs. saline within genotype (p < 0.01), and †† indicates genotype effect within AICAR treated samples (p < 0.01).