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. 2015 Mar 24;6:85. doi: 10.3389/fphys.2015.00085

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Copyright © 2015 Brandauer, Andersen, Kellezi, Risis, Frøsig, Vienberg and Treebak.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AICAR-induced upregulation of SIRT3 and MnSOD protein in mouse skeletal muscle is dependent on PGC-1α. WT and PGC-1α KO mice received daily subcutaneous injection of AICAR (500 mg/kg body weight) or saline for 4 weeks. Quadriceps muscles were obtained the day after the last injection. (A) SIRT3 protein, (B) MnSOD protein, (C) SIRT1 protein, (D) Catalase protein, (E) SIRT3 mRNA, (F) MnSOD mRNA (n = 9–10). mRNA levels of (G) SIRT3 and (H) MnSOD were obtained from quadriceps muscles from WT and PGC-1α KO mice 4 h after a single injection of saline or AICAR (500 mg/kg body weight, n = 6–8). Values are mean ± SEM. Interaction effects (treatment × genotype) were present for data in (A, C) (p < 0.05), ^** indicates vs. WT saline (p < 0.01), †† indicates genotype effect vs. WT (p < 0.01).