Table 1.
Demographic, serologic, and clinical characteristics of individuals with repeat dengue virus infections
| All data (n = 502 individuals) a | Cohort extended dataset (n = 205) | |
|---|---|---|
| Gender | ||
| Female | 252 | 100 |
| Male | 237 | 95 |
| Unknown | 13 | 10 |
| Age | ||
| At infection one (mean years ± SD) | 7.6 ± 3.0 | 9.0 ± 1.7 |
| At infection two (mean years ± SD) | 11.2 ± 3.0 | 11.2 ± 2.0 |
| Serologic response at infection one b | ||
| Primary | 84 | 6 |
| Secondary | 263 | 59 |
| Unknown (symptomatic) | 15 | - |
| Unknown (Subclinical/nonhospitalized) | 56 | 56 |
| Unknown (Subclinical) | 84 | 84 |
| Clinical category at infection one c | ||
| Symp. (DHF) | 201 | 24 |
| Symp. (DHF/hospitalized DF) | 16 | 3 |
| Symp. (hospitalized DF) | 123 | 16 |
| Symp. (non-hospitalized DF) | 19 | 19 |
| Symp. (hospitalized/non-hospitalized DF) | 3 | 3 |
| Subclinical/non-hospitalized | 56 | 56 |
| Subclinical | 84 | 84 |
| Clinical category at infection two c | ||
| Symp. (DHF) | 201 | 17 |
| Symp. (DHF/hospitalized DF) | 13 | - |
| Symp. (hospitalized DF) | 112 | 16 |
| Symp. (non-hospitalized DF) | 33 | 29 |
| Symp. (hospitalized/non-hospitalized DF) | 1 | 1 |
| Subclinical/non-hospitalized | 42 | 42 |
| Subclinical | 100 | 100 |
a488 individuals had two detected infections; 14 had three detected infections.
bThe serologic response could not be categorized in 155 individuals; 140 could not be categorized because they were either subclinical (n = 84) or had seroconversion outside the active surveillance period in cohort studies (n = 56); 15 were symptomatic but had inadequate samples to determine serologic response.
cSubclinical infections in cohort studies were identified by ≥ four-fold rise in dengue hemagglutination inhibition (HAI) titers without detection of symptomatic infection during the intervening surveillance period. Infections captured outside the active study surveillance period by HAI without a recognized hospitalization were marked as ‘subclinical/non-hospitalized’. Hospitalized cases that did not have sufficient clinical information for clinical categorization were marked ‘DHF/hospitalized DF.’ Four infections categorized as DF but with uncertain hospitalization status were marked as ‘hospitalized/non-hospitalized DF’.