Figure 9.
The modeled concentrations (in silico data) of (−)-cocaine, cocaethylene, and norcocaine in human blood when the initial concentrations of (−)-cocaine, cocaethylene, and norcocaine are 61, 34, and 5 μM, respectively. (A) to (C) refer to the time-dependent concentrations in the presence of wild-type human BChE (without E12-7), whereas (D) to (F) refer to the time-dependent concentrations in the presence of 0.07 μM E12-7.