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. 2015 Mar 24;6:220. doi: 10.3389/fmicb.2015.00220

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Copyright © 2015 Goeijenbier, Meijers, Anfasa, Roose, van de Weg, Bakhtiari, Henttonen, Vaheri, Osterhaus, van Gorp, Martina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Plasminogen activator inhibitor type 1 production, surface expression of ανβ3-integrin and PAI-1 vitronectin complex formation in HUVEC infected with PUUV. Total plasminogen activator inhibitor type-1 (PAI-1) concentration was significantly increased on time points 48 post PUUV infection (black; one way ANOVA, p < 0.05; A) compared to BPL inactivated control (gray) or negative medium control (white). Panel B shows the PAI-1 vitronectin complex levels in HUVEC infected with PUUV (black) or non-infected controls (white). After 48 h of infection PAI-1 vitronectin levels were increased compared to the mock infection (Mann–Whitney U p = 0.03; B). Data are representative of three independent experiments. ^∗p < 0.05.