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. Author manuscript; available in PMC: 2015 Aug 20.
Published in final edited form as: Neuroreport. 2014 Aug 20;25(12):926–931. doi: 10.1097/WNR.0000000000000210

Figure 1.

Figure 1

A) Brain map depicting whole-brain voxel-wise ANOVA F-map showing a significant Group × Genotype × Emotion interaction in the insula in response to fearful and happy faces. B) Bar graph depicts extracted BOLD signal change from insula region of interest showing right and left insula reactivity to fearful faces is greater in gSAD patients with SS than patients with LaLa, who showed reduced insula activation (gSAD SS >gSAD LaLa; right p<0.04, left p<0.02); in the HC group, right insula response to happy faces was greater in controls with LaLa than for controls with the SS genotype (HC LaLa> HC SS, p<0.05).

gSAD, Generalized Social Anxiety Disorder; Healthy Control (HC); SS, short allele for the serotonin transporter gene; LaLa, long allele for the serotonin transporter gene