Table 2.
REST-associated genes with significant changes in H3K27me3 levels were measured in Rest−/− ESCs
| Gene Symbol | Gene Name | Change in Rest−/− ESC |
|---|---|---|
| Prune2 | Prune homolog 2 | 2.1 |
| Fosb | FBJ osteosarcoma oncogene B | 2.0 |
| Mast1 | Microtubule associated serine/threonine kinase 1 | 1.8 |
| Celf4 | Bruno-like 4, RNA binding protein | 1.7 |
| Kiaa1152 | Uncharacterized protein C14orf118 homolog | 1.7 |
| Dner | Delta/notch-like EGF-related receptor | 1.6 |
| Cacng2 | Stargazin | 1.6 |
| Bdnf | Brain derived neurotrophic factor | 1.6 |
| Hes3 | Hairy and enhancer of split 3 | 1.6 |
| Otop3 | Otopetrin 3 | 1.5 |
| A330050F15Rik | Uncharacterized protein LOC320722 | 1.5 |
| Skor2 | SKI family transcriptional corepressor 2 | 1.4 |
| Nmnat2 | Nicotinamide nucleotide adenylyltransferase 2 | −1.3 |
| Cnnm1 | Cyclin M1 | −1.3 |
| Cabp1 | Calcium binding protein 1 | −1.5 |
| Kcnb1 | K+ voltage gated channel, Shab-related subfamily | −1.6 |
| Celsr3 | Flamingo homolog 1 | −1.7 |
| Mapt | Microtubule-associated protein tau isoform a | −1.7 |
| Bsn | Bassoon | −2.2 |
| Vgf | VGF nerve growth factor inducible | −4.4 |
| Sarm1 | Sterile alpha and TIR motif containing 1 | −12.1 |
| Galnt9 | Polypeptide Gal NAc transferase 9 | Loss |
| Smpd3 | Sphingomyelin phosphodiesterase 3 | Loss |
| Scn8a | Na2+ voltage-gated channel, type VIM, alpha | Loss |
List of genes located near REST bound regions that were associated with PRC2 in WT ESCs and showed a significant difference in H3K27me3 enrichment relative to Rest−/− ESCs.