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. Author manuscript; available in PMC: 2015 Mar 24.
Published in final edited form as: J Leukoc Biol. 2002 May;71(5):881–889.

Figure 4.

Figure 4

Effect of specific PTK family inhibitors on Mø ingestion of apoptotic thymocytes. A-D: Src family inhibitors. Resident PMø (A, B) and AMø (C, D) from normal C57BL/6 mice were pre-incubated with medium (open squares) or with medium containing 30 μM PP2 (dark stippled) or the inactive control PP3 (light cross-hatched) for 10 min at 37°C and then co-incubated with apoptotic thymocytes as previously described in the same concentration of the inhibitor for 90 minutes. Note differences in scales between PMø and AMø. Similar results were obtained in a separate experiment using PP2 and PP3 at 50 μM. E, F: Syk family inhibitor. Resident PMø (open circles) and AMø (closed squares) from normal C57BL/6 mice were pre-incubated with various concentration of piceatannol for 10 min at 37°C and then co-incubated with apoptotic thymocytes in the same concentration of the inhibitor for 90 minutes. Data are percentage phagocytosis positive Mø (A, C, E) and phagocytic index (B, D, F) as mean ± SEM of at least three replicates in a single experiment. Similar results were found in a separate experiment. *, p<0.05, unpaired t test.