Table 1.
Regressions of the externalizing disorder composite onto polygenic scores and covariates in adolescents and young adults. Model I includes gender and age as covariates. Model II includes gender, age, and parental externalizing disorder (ED) history as covariates.
| ADOLESCENTS | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| Model I (N = 246) | Model II (N = 246) | |||||
|
|
||||||
| B | SE B | t | B | SE B | t | |
|
|
||||||
| Intercept | -2.48 | 0.24 | -10.45 | -2.57 | 0.24 | -10.75 |
| Polygenic score | 6.33 | 1.33 | 4.74 | 5.85 | 1.51 | 3.87 |
| Gender | -0.10 | 0.04 | -2.34 | -0.09 | 0.04 | -2.06 |
| Age | 0.12 | 0.01 | 8.34 | 0.12 | 0.01 | 8.61 |
| Parental history | ||||||
| Either parent ED | -- | -- | -- | set as reference | ||
| Neither parent ED | -- | -- | -- | -0.08 | 0.05 | -1.68 |
| Incomplete parent ED history | -- | -- | -- | 0.12 | 0.06 | 2.09 |
|
| ||||||
| YOUNG ADULTS | ||||||
|
| ||||||
| Model I (N = 190) | Model II (N = 190) | |||||
|
| ||||||
| B | SE B | t | B | SE B | t | |
|
| ||||||
| Intercept | 0.36 | 0.49 | 0.46 | 0.54 | 0.50 | 1.08 |
| Polygenic score | 12.62 | 3.00 | 4.21 | 10.49 | 3.34 | 3.14 |
| Gender | 0.00 | 0.10 | 0.04 | 0.01 | 0.10 | 0.06 |
| Age | -0.02 | 0.02 | -1.06 | -0.03 | 0.22 | -1.25 |
| Parental history | ||||||
| Either parent ED | -- | -- | -- | set as reference | ||
| Neither parent ED | -- | -- | -- | -0.18 | 0.11 | -1.53 |
| Incomplete parent ED history | -- | -- | -- | -0.30 | 0.11 | -2.61 |
Note. Bolded statistics significant at p < .05. Bolded and italicized statistics significant at p < .01. The ‘neither parent ED’ contrast was not significant in the multivariate model for adolescents or young adults; however, it did have univariate main effects in the respective models (B = -0.25, t = -6.68, p < 0.001 and B = -0.44, t = -3.21, p < 0.001, respectively).