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. 2015 Mar 3;112(11):3457–3462. doi: 10.1073/pnas.1414558112

Fig. 1.

Fig. 1.

QS bacterial drug delivery. (A) The p(luxI) promoter controls one operon consisting of genes encoding for proteins LuxR, GFP, and LuxI. LuxI produces the communication molecule 3OC6HSL. The p(luxI) promoter responds to LuxR protein bound to 3OC6HSL. As the density of bacteria increases, 3OC6HSL concentration increases within the cell, creating a positive feedback loop that increases transcription of the operon. (B) QS bacteria will only turn on expression in high-density colonies in tumor tissue. Gray and green bacteria represent uninduced and induced bacteria, respectively. Blue dots represent 3OC6HSL.