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. 2015 Mar 19;10:2229–2248. doi: 10.2147/IJN.S79840

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Preparation of DOX-LTSL-CREKA.

Notes: The schematic representation of synthesis of DSPE-PEG-CREKA (A). DOX-LTSL-CREKA, composed of DPPC, MSPC, DSPE-PEG, and DSPE-PEG-CREKA (86:10:2:2 molar ratio), was prepared by a thin-film hydration method (B). The DOX/lipid (w/w) ratio was 1:20. The schematic representation depicting the central concept of DOX-LTSL-CREKA (C). The encapsulated DOX was in the thermosensitive liposomes at 37°C. The encapsulated DOX immediately released from thermosensitive liposomes during hyperthermia treatment (43°C). Typical particle size and distribution of the DOX-LTSL-CREKA (D). The particle size of DOX-LTSL-CREKA during hyperthermia treatment (43°C) for 10 minutes (E).

Abbreviations: DOX, doxorubicin; LTSL, lysolipid-containing thermosensitive liposome; CREKA, Cys-Arg-Glu-Lys-Ala; DSPE-PEG, 1,2-distearoyl-sn-glycero-3-phos phatidylethanolamine-N-[methoxy(polyethylene glycol)-2000]; DPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine; MSPC, mono-stearoyl-sn-glycero-3-phos-phatidylcholine; DSPE-PEG-MAL, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000]; PBS, phosphate-buffered saline.

Preparation of DOX-LTSL-CREKA.

Notes: The schematic representation of synthesis of DSPE-PEG-CREKA (A). DOX-LTSL-CREKA, composed of DPPC, MSPC, DSPE-PEG, and DSPE-PEG-CREKA (86:10:2:2 molar ratio), was prepared by a thin-film hydration method (B). The DOX/lipid (w/w) ratio was 1:20. The schematic representation depicting the central concept of DOX-LTSL-CREKA (C). The encapsulated DOX was in the thermosensitive liposomes at 37°C. The encapsulated DOX immediately released from thermosensitive liposomes during hyperthermia treatment (43°C). Typical particle size and distribution of the DOX-LTSL-CREKA (D). The particle size of DOX-LTSL-CREKA during hyperthermia treatment (43°C) for 10 minutes (E).

Abbreviations: DOX, doxorubicin; LTSL, lysolipid-containing thermosensitive liposome; CREKA, Cys-Arg-Glu-Lys-Ala; DSPE-PEG, 1,2-distearoyl-sn-glycero-3-phos phatidylethanolamine-N-[methoxy(polyethylene glycol)-2000]; DPPC, 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine; MSPC, mono-stearoyl-sn-glycero-3-phos-phatidylcholine; DSPE-PEG-MAL, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000]; PBS, phosphate-buffered saline.