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. 2015 Mar 19;10:2229–2248. doi: 10.2147/IJN.S79840

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© 2015 Wang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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The flow cytometric measurement of DOX uptake from DOX-LTSL-CREKA by MCF-7/ADR cells.

Notes: Flow cytometric analyses (A) and mean fluorescence intensity (B) of MCF-7/ADR cells after 2-hour incubation with Roswell Park Memorial Institute 1640 medium (black line), free DOX unheated (red line), DOX-LTSL-CREKA unheated (green line), and DOX-SSL unheated (blue line) (a); free DOX heated at 43°C for 5 minutes before incubation (red fill), DOX-LTSL-CREKA heated at 43°C for 5 minutes before incubation (green fill), and DOX-SSL heated at 43°C for 5 minutes before incubation (blue fill) (b); free DOX heated at 43°C for 5 minutes after incubation (red grid line), DOX-LTSL-CREKA heated at 43°C for 5 minutes after incubation (green grid line), and DOX-SSL heated at 43°C for 5 minutes after incubation (blue grid line) (c); DOX-LTSL-CREKA unheated (green line), DOX-LTSL-CREKA heated at 43°C for 5 minutes before incubation (green fill), and DOX-LTSL-CREKA heated at 43°C for 5 minutes after incubation (green gird line) (d); DOX-SSL unheated (blue line), DOX-SSL heated at 43°C for 5 minutes before incubation (blue fill), and DOX-SSL heated at 43°C for 5 minutes after incubation (blue gird line) (e). **P<0.01 vs DOX-SSL; ^##P<0.01 vs free DOX; ^&&P<0.01 vs unheated treatment; ^‡‡P<0.01 vs heated before incubation treatment.

Abbreviations: DOX, doxorubicin; LTSL, lysolipid-containing thermosensitive liposome; CREKA, Cys-Arg-Glu-Lys-Ala; SSL, sterically stabilized liposomes.