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. 2015 Mar 19;10:2229–2248. doi: 10.2147/IJN.S79840

Figure 4.

Figure 4

The confocal microscopy images of MCF-7/ADR cells incubated with DOX-LTSL-CREKA.

Notes: Confocal microscopy images of MCF-7/ADR cells incubated with DOX-LTSL-CREKA, DOX-SSL, and free DOX at unheated condition (a), with heating before incubation at 43°C for 5 minutes (b), and with heating after incubation at 43°C for 5 minutes (c) (A). Red is fluorescence of doxorubicin and blue is fluorescence of nuclei staining. Overlaying pictures of Hoechst 33258 and DOX are also shown (B) MCF-7/ADR cells incubated with DOX-LTSL-CREKA, DOX-SSL and free DOX at un-heated (a), with heating before incubation at 43°C for 5 minutes (b), with heating after incubation at 43°C for 5 minutes (c).

Abbreviations: DOX, doxorubicin; LTSL, lysolipid-containing thermosensitive liposome; CREKA, Cys-Arg-Glu-Lys-Ala; SSL, sterically stabilized liposomes.