Figure 6.
Localization of DiI-LTSL-CREKA in tumor tissue.
Notes: BALB/c nude mice bearing MCF-7/ADR tumors (~200 mm3) were intravenously injected with DiI-LTSL-CREKA at a dose of 200 μg/kg. At 2-hour or 6-hour time point, the mice in the experiment were sacrificed, the tumors were harvested, and tumor sections were examined for fluorescence. DiI-LTSL-CREKA (red) accumulates in tumor blood vessels (anti-CD31, green) (A) and co-localizes with anti-fibrin (ogen) (green) staining (B). The results are representative of four independent experiments. Magnification: ×200.
Abbreviations: DiI, 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindocarbocyanine perchlorate; LTSL, lysolipid-containing thermosensitive liposome; CREKA, Cys-Arg-Glu-Lys-Ala.