Table 2.
The IC50 (μg/mL) values of DOX-LTSL-CREKA with or without heating at 43°C for 5 minutes in MCF-7/ADR and MCF-7 cells (n=3)
| DOX-LTSL-CREKA | DOX-LTSL | DOX-SSL | Free DOX | ||
|---|---|---|---|---|---|
| MCF-7/ADR | Unheated | 117.55±2.82 | 125.86±2.30 | 131.80±2.04 | 65.58±4.93 |
| Heated | 71.21±2.13 | 74.01±1.38 | 117.34±2.57 | 60.31±2.28 | |
| MCF-7 | Unheated | 5.09±0.24 | 4.97±0.27 | 7.76±0.24 | 0.74±0.05 |
| Heated | 1.22±0.12 | 1.40±0.10 | 6.83±0.26 | 0.70±0.02 |
Abbreviations: DOX, doxorubicin; LTSL, lysolipid-containing thermosensitive liposome; CREKA, Cys-Arg-Glu-Lys-Ala; SSL, sterically stabilized liposomes; IC50, inhibitory concentration 50.