. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: Pediatr Nephrol. 2014 Dec 5;30(4):665–676. doi: 10.1007/s00467-014-2987-0

Table 3.

Area under the receiver operating characteristic curve for biomarkers to discriminate for the presence of a) SCr-AKI and b) CysC-AKI¹ when biomarkers were obtained on the day of AKI attainment.

Biomarker on 1^st AKI day	SCrAKIAUC² (95% CI)	Biomarker cut-off for 85%) Specificity³ (associated sensitivity) 85%) Sensitivity⁴ (associated specificity)	CysC AKI AUC² (95% CI)	Biomarker cut-off for 85%) Specificity³ (associated sensitivity) 85%) Sensitivity⁴ (associated specificity)
Urine NGAL (ng/mg creat)	0.68^* (0.55 – 0.81)	196 ng/mg (39%) sensitivity) 12 ng/mg (24% specificity)	0.70^# (0.58-0.83)	276 (27% sensitivity) 23 (47% specificity)
Urine IL-18 (pg/mg creat)	0.68^* (0.55 – 0.80)	255 pg/mg (32% sensitivity) 23 pg/mg (35%) specificity)	0.54 (0.40 - 0.69)	274 (18% sensitivity) 17 (27% specificity)
Urine KIM-1 (pg/mg creat)	0.61 (0.48 - 0.74)	3356 pg/mg (17%) sensitivity) 180 pg/mg (29% specificity)	0.61 (0.47 – 0.75)	4479 (15% sensitivity) 195 (28% specificity)
Urine CysC (mg/mg creat)	0.52(0.38 – 0.66)	0.62 mg/mg (14%) sensitivity) 0.76 mg/mg (26%) specificity)	0.52(0.38 – 0.66)	0.62 (10% sensitivity) 0.88 (27% specificity)

Abbreviations: SCr: serum creatinine; SCr-AKI: acute kidney injury defined by SCr rise., CysC: Cystatin C; CysC-AKI: acute kidney injury defined by CysC rise; AUC: area under the receiver operating characteristic curve; NGAL: neutrophil gelatinase-associated lipocalin; IL-18: interleukin-18; KIM-1: kidney injury molecule-1.

Area under the curve for biomarkers to discriminate for the presence of SCr-AKI (left) and CysC-AKI (right).

biomarker concentrations which resulted in 85% specificity to diagnose AKI were chosen; the sensitivity at that concentration is provided.

⁴

biomarker concentrations which resulted in 85% sensitivity to diagnose AKI were chosen; the specificity at that concentration is provided.

AUC for NGAL and IL-18 were significantly higher for SCr-AKI diagnosis than KIM-1 and urine CysC (p<0.05)

AUC for NGAL was significantly higher for CysC-AKI diagnosis than IL-18, KIM-1, and urine CysC (p<0.05)