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. 2014 Nov 22;6(2):316–330. doi: 10.1021/cn5002182

Figure 4.

Figure 4

Effect on frequency (use)-dependent block by the chimeric compounds (R)-7–(R)-10 on Na+ currents in CAD cells. (A) Frequency dependence of block was examined by holding cells at the hyperpolarized potential of −80 mV and evoking currents at 10 Hz by 20 ms test pulses to −10 mV (inset middle). Summary of average frequency (use)-dependent decrease in current amplitude over time (±SEM) produced by control (0.1% DMSO) or by the presence of 10 μM of the indicated compounds are shown (p > 0.05, one-way ANOVA with Dunnett’s post hoc test). (B) Summary of the maximal decrement in current amplitude observed at the 30th pulse for control (0.1% DMSO) or the indicated compounds. (R)-9 and (R)-10 caused a significant decrease in current amplitude compared with control (*p < 0.05, one-way ANOVA with Dunnett’s post hoc test; n = 5–8 cells).