Table 2. Pharmacological Activity of the Substituted (R)-N-4-(Benzyloxy)benzyl 2-Acetamido-3-methoxypropionamide Derivatives in the Formalin Pain Model.
compd | dose (mg/kg)a | phase I (acute)b | phase II (inflammatory)b |
---|---|---|---|
(R)-7 | 5.0 | 41 | 72 |
(R)-8 | 7.0 | 85 | 103 |
(R)-9 | 12 | 114 | 98 |
(R)-10 | 8.0 | 66 | 55 |
(R)-1 | 9.0 | 39 | 63 |
(R)-4 | 5.8 | 77 | 52 |
(R)-5 | 7.0 | 69 | 49 |
(R)-6 | NDc |
Compounds administered to mice by ip.
Percent time spent licking (s) of control.
ND = not determined.