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. 2014 Nov 22;6(2):316–330. doi: 10.1021/cn5002182

Table 2. Pharmacological Activity of the Substituted (R)-N-4-(Benzyloxy)benzyl 2-Acetamido-3-methoxypropionamide Derivatives in the Formalin Pain Model.

compd dose (mg/kg)a phase I (acute)b phase II (inflammatory)b
(R)-7 5.0 41 72
(R)-8 7.0 85 103
(R)-9 12 114 98
(R)-10 8.0 66 55
(R)-1 9.0 39 63
(R)-4 5.8 77 52
(R)-5 7.0 69 49
(R)-6 NDc    
a

Compounds administered to mice by ip.

b

Percent time spent licking (s) of control.

c

ND = not determined.