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. Author manuscript; available in PMC: 2015 Mar 24.
Published in final edited form as: Sci Signal. 2014 Sep 23;7(344):re8. doi: 10.1126/scisignal.2005189

Fig. 6. Matrix signaling in EMT.

Fig. 6

Type I collagen induces EMT through integrin or DDR1/2 signaling. Both types of receptors activate NF-κB and other transcription factors (TFs) that promote expression of SNAI1/2 and LEF1. Other pathways simplified here, such as those mediated by PI3K, ILK, proline-rich tyrosine kinase 2 (PYK2)–PDK1, and FAK-paxillin, are activated by type I collagen through integrins and DDRs, ultimately promoting the stabilization and activity of the EMT-associated transcription factors Snail1/2 and LEF-1. DDR1 is also known to form complexes with E-cadherin at the cell surface, which are disrupted upon binding to type I collagen.