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. Author manuscript; available in PMC: 2015 Mar 24.
Published in final edited form as: Nature. 2004 Sep 19;432(7013):59–67. doi: 10.1038/nature02976

Figure 1.

Figure 1

Quaternary rearrangements in the integrin ectodomain. a–c, Three conformational states visualized in electron microscopy3,6 and in crystal structures (here and in ref. 7). d–j, Proposed intermediates in equilibration between known conformational states. The upper pathways may be stimulated by ligand binding outside the cell, and the lower pathways by signals within the cell that separate the α and β subunit transmembrane domains. Domains in a–j are shown in solid colour if known directly from crystal structures, dashed with grey if placed from crystal structures into electron microscopy image averages, and in solid grey for EGF-1 and EGF-2, which are modelled on EGF-3 and EGF-4.