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. Author manuscript; available in PMC: 2015 Mar 24.
Published in final edited form as: Biochem J. 2011 Nov 1;439(3):403–411. doi: 10.1042/BJ20102167

Figure 4. Histological abnormalities of Pla2g4a−/− testes.

Figure 4

Histological analysis of testes from juvenile 44-day-old Pla2g4a+/+ (A and B) and Pla2g4a−/− (C–F) mice, and fully mature 119-day-old Pla2g4a+/+ (G) and 122-day-old Pla2g4a−/− (H) mice. Representative cross-sections (A, C, E, G and H) and parallel sections (B, D and F) of haematoxylin and eosin-stained seminiferous tubules are shown. Juvenile wild-type testes show a highly integrated structure of seminiferous tubules with normal spermatogenesis within them. In the testes of juvenile Pla2g4a−/− mice, elongated spermatids were also seen. However, the structure of the seminiferous epithelium tends to be disorganized and loose and disrupted junctions are evident among tubules. Pla2g4a−/− testes (H) as well as Pla2g4a+/+ testes (G) of approximately 120-day-old mice appear histologically normal. Scale bar is 100 μm and is applicable for all panels.