Table 2. The Time-Dependent Inhibition upon Inhibitors against HDAC1–3a.
IC50 (μM) |
|||
---|---|---|---|
compound | HDAC1 | HDAC2 | HDAC3 |
β-hm-chalcone | 3.68 (2.74) | 9.19 (0.17) | ∼50 (∼50) |
β-am-chalcone | 5.96 (8.65) | 19.64 (26.44) | >50 (>50) |
MS-275 | 2.26 (0.80) | 6.42 (4.13) | 9.37 (7.95) |
Data order: 1 h (24 h); the detailed curves refer to Figure S9. β-am-chalcone: β-aminomethyl chalcone. β-hm-chalcone: β-hydroxymethyl chalcone.