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. 2014 Dec 29;10(3):687–692. doi: 10.1021/cb500767c

Table 2. The Time-Dependent Inhibition upon Inhibitors against HDAC1–3a.

  IC50 (μM)
compound HDAC1 HDAC2 HDAC3
β-hm-chalcone 3.68 (2.74) 9.19 (0.17) ∼50 (∼50)
β-am-chalcone 5.96 (8.65) 19.64 (26.44) >50 (>50)
MS-275 2.26 (0.80) 6.42 (4.13) 9.37 (7.95)
a

Data order: 1 h (24 h); the detailed curves refer to Figure S9. β-am-chalcone: β-aminomethyl chalcone. β-hm-chalcone: β-hydroxymethyl chalcone.