Figure 1.

HDAC inhibitors used in the study. Structures of the small molecule inhibitors used in the study. The HDAC specificity of the small molecules are as follows: SAHA (HDAC 1, 2, 3, 6, 8), crebinostat (HDAC 1, 2, 3, 6), CI-994 (HDAC 1, 2, 3), Cpd-60 (HDAC 1, 2), BG-45 (HDAC3), tubacin (HDAC6), ACY-1215 (HDAC6), tubastatin A (HDAC6), PCI-34051 (HDAC8). IC₅₀ values (μM) of the small molecules for inhibition of different HDAC isoforms are showed in Table 1.^{31,36,37,44,55−57}