Table 1.

Isoform specificity of small molecule inhibitors of NADPH oxidase

Name	Structure	IC50s (µM)				References
		Nox1	Nox2	Nox4	XO
VAS2870		↓	10.6 (Neutrophils) 2 (HL-60)	↓	?	[52–58]
VAS3947		↓	1–2 (HL-60 cells)	↓	–	[60]
Fulvene-5		?	↓	↓	?	[63]
ML171		0.25	5.00	5.00	5.50	[70]
GKT 136901		0.160a	1.530a	0.165a	30a	[64–66, 79, 80]
Celastrol		0.41	0.59	2.7	–	[74]

↓ inhibits, – no effect, ? not determined

^a K _i in µM