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. Author manuscript; available in PMC: 2016 Mar 1.
Published in final edited form as: Cell Mol Bioeng. 2014 Dec 9;8(1):160–177. doi: 10.1007/s12195-014-0370-7

Figure 10.

Figure 10

Effect of PAK inhibition on stretch-induced SF reorientation. (A–B) ECs were pretreated with (A) control peptide or (B) PAK-Nck inhibitory peptide for 1 h and subjected to cyclic uniaxial stretch for 4 h. Arrows indicate stretch directions. Scale bar, 20 μm. Rose plots show normalized angular distribution of F-actin orientations computed in 64×64-pixel subimages (n > 3000 subimages in 15 fields of view in 3 experiments). (C) Circular variance of SF orientations within individual fields of view. On each box, central mark: median; edges: 25th and 75th percentiles; whiskers: most extreme data points. (n = 15 fields of view in 3 experiments)