Table 1.

Summary of H4K12ac lacking promoters in spermatozoa of subfertile patients

Function of promoters depleted for H4K12ac binding in sperm chromatin of subfertile patients		References
AFF4	AF4/FMR2 family member 4, AFF4-deficient mice male mice are sterile with azoospermia and their outcomes died in utero and neonatally with impaired embryonic development.	Urano et al. [39]
NCOA6	Nuclear receptor co-activator 6; involved in the co-activation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR), and prostanoids (PPARs).	Li and Xu [40]
RUVBL1	RuvB-like 1, TATA box-binding protein-interacting protein, component of the NuA4 histone acetyltransferase complex.	Yamauchi et al. [41], Choudhary et al. [42]
NSD1	Histone methyltransferase, methylates ‘Lys-36’ of histone H3 and ‘Lys-20’ of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription. Defects in NSD1 are a cause of Beckwith-Wiedemann syndrome.	Tatton-Brown and Weksberg [43], Crea [44], Baujat et al. [45]
EP300	Histone acetyltransferase p300; regulates transcription via chromatin remodeling.	Zhang et al. [46]
LRP5	Low-density lipoprotein receptor-related protein 5; forms phosphorylated oligomer aggregates on Wnt-signaling. Required for posterior patterning of the epiblast during gastrulation.	Joiner et al. [47]
POU2F1	POU domain, class 2, transcription factor 1. Transcription factor that binds to the octamer motif (5′-ATTTGCAT-3′) and activates the promoters of the genes for some small nuclear RNAs.	Latchman [48]