Fig 2. Airway reactivity is reduced in JH^-/- mice.

WT or JH^-/- mice were intranasally exposed to OAAH or PBS for 2 weeks, as described in Fig. 1A. (A) Airway reactivity to inhaled methacholine was assessed by whole-body plethysmography, as described in the Methods section. Results are presented as the percentage of baseline (i.e. before PBS or methacholine challenge) and as mean±SEM (n = 4 and 6 in PBS and OAAH, respectively). *, p<0.05, between WT mice and JH^-/- mice exposed to OAAH. (B) Lung sections were stained with the periodic acid-Schiff stain. Original magnification, 160×. Scale bars, 50 μm. Data are representative of two independent experiments.