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. Author manuscript; available in PMC: 2015 Mar 24.
Published in final edited form as: Am J Gastroenterol. 2010 Oct 26;106(2):264–271. doi: 10.1038/ajg.2010.412

Table 3.

Operating characteristics of tryptase staining for diagnosis of EoE

Tryptase
density
(96 mast
cells/mm2)† 		Eosinophil
count
(50 eos/hpf)‡ 		Eosinophil
count
(15 eos/hpf)# 		Tryptase and
eosinophils
(96 cells/mm2;
50 eos/hpf)		 Tryptase and
eosinophils
(96 cells/mm2;
15 eos/hpf)
ROC AUC 0.84 0.89 0.89 0.96 0.96
Sensitivity (%) 80 80 98 91 98
Specificity (%) 80 84 19 95 63
Positive LR 4 5 1.2 18 2.6
Negative LR 0.25 0.24 0.11 0.09 0.03

Abbreviations: ROC AUC = receiver operator characteristic area under the curve; LR = likelihood ratio; eos/hpf = eosinophils per high-power field.

*

Parameters were calculated for tryptase staining alone, eosinophil count alone, and tryptase staining with eosinophil count combined in comparison to consensus guidelines for diagnosis of EoE as the gold standard (1).

†

This is the tryptase density that maximizes sensitivity and specificity in this dataset.

‡

This is the eosinophil count that maximizes sensitivity and specificity in this dataset. An eosinophil count of 50 eos/hpf equals an eosinophil density of 207 eos/mm2 assuming a hpf size of 0.24 mm2.

#

An eosinophil count of 15 eos/hpf equals an eosinophil density of 63 eos/mm2 assuming a hpf size of 0.24 mm2.